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人才隊伍

劉小龍
研究員，研究組長，博士生導(dǎo)師，中心主任
E-mail: xiaolongliu@@sibcb.ac.cn
實驗室主頁:

個人簡介：

　　1994年畢業(yè)于南昌大學(xué)，獲有機(jī)化學(xué)專業(yè)學(xué)士學(xué)位;1999年畢業(yè)于中國科學(xué)院上海生物化學(xué)研究所，獲生物化學(xué)與分子生物學(xué)專業(yè)博士學(xué)位;1999年至2004年在美國國立癌癥研究所(National Cancer Institute, NIH)接受博士后訓(xùn)練，從事細(xì)胞免疫學(xué)研究。2004年聘為研究員;2009年入選國家杰出青年科學(xué)基金獲得者;2014年入選科技部中青年科技創(chuàng)新領(lǐng)軍人才。擔(dān)任國家重點(diǎn)基礎(chǔ)研究發(fā)展計劃(973計劃)項目首席(2013年-2017年)，國家自然科學(xué)基金創(chuàng)新群體項目負(fù)責(zé)人(2017年-)。近年來，系統(tǒng)性研究了免疫細(xì)胞的分化成熟及其功能作用機(jī)制，在Nat Immunol, Nat Commun, JEM, PNAS和EMBO J等學(xué)術(shù)期刊上發(fā)表50余篇研究論文。2008年獲得明治乳業(yè)生命科學(xué)獎;2009年獲得第十一屆中國青年科技獎;2010年評為中科院優(yōu)秀研究生指導(dǎo)教師;2011年評為全國優(yōu)秀博士學(xué)位論文指導(dǎo)教師;2012年獲得A-IMBN Research Young Investigators Award。擔(dān)任Cell Res和J Biol Chem等學(xué)術(shù)期刊的編委;任中國生物化學(xué)與分子生物學(xué)會副理事長，秘書長。

社會任職：

研究方向：

免疫細(xì)胞分化與功能

研究工作：

　　免疫細(xì)胞在骨髓或胸腺中分化成熟，遷移至外周淋巴系統(tǒng)中發(fā)揮免疫功能。我們研究組的科研工作以T細(xì)胞、NK細(xì)胞和中性粒細(xì)胞為主要研究對象，圍繞他們的分化成熟與功能調(diào)控機(jī)制而展開。在T細(xì)胞方面，主要研究其定向分化及其在腫瘤免疫調(diào)控中的分子細(xì)胞作用機(jī)制;在NK細(xì)胞方面，主要聚焦其功能發(fā)揮與失調(diào)及功能改造技術(shù);在中性粒細(xì)胞方面，主要探索其在彌散性血栓中的作用機(jī)制及干預(yù)策略。

承擔(dān)科研項目情況：

代表論著：

1. Xu Y, Luo H, Wang J, Liu H, Chen L, Ji H, Deng Z*,?Liu X*. CD103⁺?T cells eliminate damaged alveolar epithelial type II cells under oxidative stress to prevent lung tumorigenesis. Adv Sci (Weinh). 2025: e2503557
2. Qin Z, Jiang Y, Tao P, Liu H, Zhong H, Ding X, Zhao R, Lu Y, Zhang L, Chen X, Zhuang H, Wu J, Deng Z, Liu X*. A ready-to-use RNA delivery platform modulated by metal ions. Chem Eng J. 2025; 506:e160170
3. Bao W, Xing H, Cao S, Long X, Liu H, Ma J, Guo F, Deng Z*,?Liu X*. Neutrophils restrain sepsis associated coagulopathy via extracellular vesicles carrying superoxide dismutase 2 in a murine model of lipopolysaccharide induced sepsis.?Nat Commun. 2022; 13(1):4583.
4. Hu C, Chen B, Li Z, Yang T, Xu C, Yang R, Yu P, Zhao J, Liu T, Liu N, Shan B, Zhang Q, Song J, Fei M, Zong L, Zhang J, Wu J, ChenS, Wang Y, Chang B, Hou D, Liu P, Jiang Y, Li X, Chen X, Deng C, Ren Y, Wang R, Jin J, Xue K, Zhang Y, Du M, Shi J, Wu L, Chang C, Shen S, Chen Z, Chen S,?Liu X*, Sun X*, Zheng M*, Wang L*. Targeting UHRF1-SAP30-MXD4 axis for leukemia initiating cell eradication in myeloid leukemia.?Cell Res. 2022; 32(12):1105-1123.
5. Xu Y, Ma J, Luo H, Shi Y, Liu H, Sun A, Xu C, Ji H,?Liu X*. Chromatin assembly factor 1B critically controls the early development but not function acquisition of invariant natural killer T cells in mice.?Eur J Immunol. 2021; 51(7):1698-14.
6. Shen H, Gu C, Liang T, Liu H, Guo F,?Liu X*. Unveiling the heterogeneity of NKT cells in the liver through single cell RNA sequencing.?Sci Rep.?2020; 10(1): 19453.
7. Sun A, Xu K, Liu H, Li H, Shi Y, Zhu X, Liang T, Li X, Cao X, Ji Y, Jiang T, Xu C,?Liu X*. The evolution of zebrafish RAG2 protein is required for adapting to the elevated body temperature of the higher endothermic vertebrates.?Sci Rep.?2020; 10(1): 4126.
8. Sun X, Cui Y, Feng H, Liu H,?Liu X*. TGF-β signaling controls Foxp3 methylation and T reg cell differentiation by modulating Uhrf1 activity.?J Exp Med. 2019 Sep 12. pii: jem.20190550. doi: 10.1084/jem.20190550.
9. Xu Y, Sun Y, Shen H, Dai Y, Liu H, Li R, Zhang H, Wu L, Zhu X,?Liu X*.?Regulation of the terminal maturation of iNKT cells by mediator complex subunit 23.?Nat Commun. 2018; 9(1):3875.
10. Chen X, Zhao J, Gu C, Cui Y, Dai Y, Song G, Liu H, Shen H, Liu Y, Wang Y, Xing H, Zhu X, Hao P, Guo F*,?Liu X*.?Med23 serves as a gatekeeper of the myeloid potential of hematopoietic stem cells.?Nat Commun. 2018; 9(1):3746.
11. Zhang R, Ma H, Gao Y, Wu Y, Qiao Y, Geng A, Cai C, Han Y, Zeng YA,?Liu X*, Ge G*.?Th-POK regulates mammary gland lactation through mTOR-SREBP pathway.?PLoS Genet. 2018; 14(2):e1007211.
12. Zhao J, Chen X, Song G, Zhang J, Liu H,?Liu X*. Uhrf1 controls the self-renewal versus differentiation of hematopoietic stem cells by epigenetically regulating the cell-division modes.?Proc Natl Acad Sci U S A. 2017; 114(2):E142-E151. [Highlighted by?Proc Natl Acad Sci U S A. 2017; 114(2):192-94].
13. Chen J, Cai Z, Zhang L, Yin Y, Chen X, Chen C, Zhang Y, Zhai S, Long X,?Liu X*, Wang X*.?Lis1 Regulates Germinal Center B Cell Antigen Acquisition and Affinity Maturation.?J Immunol. 2017;198(11):4304-4311.
14. Cui Y, Chen X, Zhang J, Sun X, Liu H, Bai L, Xu C,?Liu X*. Uhrf1 Controls iNKT Cell Survival and Differentiation through the Akt-mTOR Axis.?Cell Rep. 2016; 15(2):256-63.
15. Xu K, Liu H, Shi Z, Song G, Zhu X, Jiang Y, Zhou Z,?Liu X*. Disruption of the RAG2 zinc finger motif impairs protein stability and causes immunodeficiency.?Eur J Immunol. 2016; 46(4):1011-9.
16. Deng Z, Liu H, Rui J,?Liu X*. Reconstituted Thymus Organ Culture.?Methods Mol Biol.?2016; 1323:151-8.
17. Deng Z, Liu H,?Liu X*. RAG1-mediated ubiquitylation of histone H3 is required for chromosomal V(D)J recombination.?Cell Res. 2015; 25(2):181-92.
18. Sun Y, Zhu X, Chen X, Liu H, Xu Y, Chu Y, Wang G*,?Liu X*. The mediator subunit Med23 contributes to controlling T-cell activation and prevents autoimmunity.?Nat Commun. 2014; 5:5225.
19. Zhang Y, Xu K, Deng A, Fu X, Xu A*,?Liu X*. An amphioxus RAG1-like DNA fragment encodes a functional central domain of vertebrate core RAG1.?Proc Natl Acad Sci U S A. 2014; 111(1):397-402.
20. Chen X, Zhang J, Zhao J, Liu H, Sun X, Zhao M,?Liu X*. Lis1 is required for the expansion of hematopoietic stem cells in the fetal liver.?Cell Res.?2014; 24:1013-16.
21. Xiao G, Deng A, Liu H, Ge G,?Liu X*. Activator protein 1 suppresses antitumor T-cell function via the induction of programmed death 1.?Proc Natl Acad Sci U S A. 2012; 109(38):15419-24.
22. Rui J, Liu H, Zhu X, Cui Y,?Liu X*. Epigenetic silencing of CD8 genes by ThPOK-mediated deacetylation during CD4 T cell differentiation.?J Immunol. 2012; 189(3):1380-90. [Highlighted by?J Immunol. 2012; 189(3):1098].
23. Cao Y, Li H, Liu H, Zhang M, Hua Z, Ji H,?Liu X*. LKB1 regulates TCR-mediated PLCγ1 activation and thymocyte positive selection.?EMBO J. 2011; 30(10):2083-93. [Selected by?Faculty of 1000 Biology]
24. Wen X, Liu H, Xiao G,?Liu X*. Downregulation of the transcription factor KLF4 is required for the lineage commitment of T cells.?Cell Res. 2011; 21(12):1701-10.
25. Zhang M, Zhang J, Rui J,?Liu X*. p300-Mediated Acetylation Stabilizes the Th-Inducing POK Factor.?J Immunol. 2010; 185(7):3960-9. [Highlighted by?J Immunol. 2010; 185(7):3783]
26. Cao Y, Li H, Sun Y, Chen X, Liu H, Gao X and?Liu X*. Interferon regulatory factor 4 regulates thymocyte differentiation by repressing Runx3 expression.?Eur J Immunol. 2010; 40(11):3198-209.
27. Cao Y, Li H, Liu H, Zheng C, JI H,?Liu X*. The serine/threonine kinase LKB1 controls thymocyte survival by regulation of AMPK activation and Bcl-XL expression.?Cell Res. 2010; 20:99-108.
28. Zhang Y, Li H, Wang X, Gao X,?Liu X*. Regulation of T cell development and activation by creatine kinase B.?PLoS One. 2009; 4(4):e5000.
29. Yang Z, Cao Y, Zhu X, Huang Y, Ding Y,?Liu X*. Znhit1 causes cell cycle arrest and down-regulates CDK6 expression.?Biochem Biophys Res Commun. 2009; 386(1):146-52.
30. Wang X, Zhang Y, Xiao G, Gao X,?Liu X*. c-Fos enhances survival of thymocytes during positive selection by upregulating Bcl-2.?Cell Res. 2009; 19:340-347.
31. Wang X, Xiao G, Zhang Y, Wen X, Gao X, Okada S,?Liu X*. Regulation of?Tcrb?recombination ordering by c-Fos-dependent RAG deposition.?Nat Immunol. 2008; 9(7):794-801. [Research highlighted by?Nat Rev Immunol. 2008; 8(7):494]
32. Zhang Y, Yang Z, Cao Y, Zhang S, Li H, Huang Y, Ding YQ,?Liu X*. The Hsp40 family chaperone protein DnaJB6 enhances Schlafen1 nuclear localization which is critical for promotion of cell cycle arrest in T cells.?Biochem J. 2008; 413(2):239-250.
33. Shi J, Yang Z, Wang M, Cheng G, Li D, Wang Y, Zhou Y,?Liu X*, Xu C*. Screening of an antigen target for immunocontraceptives from cross-reactive antigens between human sperm and Ureaplasma urealyticum.?Infect Immun. 2007; 75(4):2004-2011.
34. Sun G,?Liu X, Mercado P, Jenkinson SR, Kypriotou M, Feigenbaum L, Galéra P, Bosselut R*. The zinc finger protein cKrox directs CD4 lineage differentiation during intrathymic T cell positive selection.?Nat Immunol. 2005; 6(4):373-381.
35. Liu X, Taylor BJ, Sun G, Bosselut R*. Analyzing expression of perforin, Runx3, and Thpok genes during positive selection reveals activation of CD8-differentiation programs by MHC II-signaled thymocytes.?J Immunol. 2005; 175(7):4465-4474.
36. Liu X, Bosselut R*. Duration of TCR signaling controls CD4-CD8 lineage differentiation in vivo.?Nat Immunol. 2004; 5(3):280-288.
37. Liu X, Adams A, Wildt KF, Aronow B, Feigenbaum L, Bosselut R*. Restricting Zap70 expression to CD4+CD8+?thymocytes reveals a T cell receptor-dependent proofreading mechanism controlling the completion of positive selection.?J Exp Med. 2003; 197(3):363-373.
38. Liu X, Wu X and Zhou Y*. Identification of key residues responsible for enzymatic and platelet-aggregation-inhibiting activities of acidic phospholipase A2 from Agkistrodon halys Pall.?J Nat Toxins. 2001; 10: 43-55.
39. Liu X, Xiong Y, Wu X and Zhou Y*. A comparative study on the structure and function of phospholipase A2s from Agkistrodon acutus.?Protein Peptide Lett. 2000; 7: 83-90.
40. Liu X, Pan H., Yang G, Wu X and Zhou Y*. Cloning, Expression and Biochemical Characterization of A Basic-Acidic Hybrid Phospholipase A2-II From Agkistrodon halys Pallas.?Biochim Biophys Acta.?1999; 1431: 157-165.

獲獎及榮譽(yù)：

研究組成員：

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