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人才隊(duì)伍

汪勝
研究員，研究組長(zhǎng)，博士生導(dǎo)師
E-mail: wangsheng@sibcb.ac.cn
實(shí)驗(yàn)室主頁(yè):

個(gè)人簡(jiǎn)介：

2007年本科畢業(yè)于武漢大學(xué)（生物科學(xué)）和華中農(nóng)業(yè)大學(xué)（食品質(zhì)量與安全），2013年博士畢業(yè)于中科院生物化學(xué)與細(xì)胞生物學(xué)研究所。2013-2018年在北卡羅來(lái)納大學(xué)教堂山分校藥理系（UNC-ChapelHill）和美國(guó)國(guó)家心理衛(wèi)生院精神藥物篩選中心（NIMH-PDSP）從事博士后研究。2018年9月加入中科院生物化學(xué)與細(xì)胞生物學(xué)研究所，任研究員、研究組長(zhǎng)、博士生導(dǎo)師。近年來(lái)，共申請(qǐng)中國(guó)發(fā)明專利7項(xiàng)，國(guó)際PCT專利3項(xiàng)。其中兩項(xiàng)專利已完成產(chǎn)業(yè)轉(zhuǎn)讓，相關(guān)化合物進(jìn)入臨床申報(bào)階段。先后入選國(guó)家杰出青年科學(xué)基金，“談家楨生命科學(xué)創(chuàng)新獎(jiǎng)”，“藥明康德生命化學(xué)研究獎(jiǎng)”等資助。

社會(huì)任職：

研究方向：

神經(jīng)精神藥物藥理及藥物設(shè)計(jì)

研究工作：

　　本研究組主要針對(duì)精神分裂癥、抑郁及焦慮癥、癡呆癥等神經(jīng)和精神疾病，開(kāi)展神經(jīng)精神藥物與其靶點(diǎn)的結(jié)構(gòu)藥理研究，以此為基礎(chǔ)展開(kāi)“更有效”“更安全”的新一代藥物設(shè)計(jì)，為神經(jīng)系統(tǒng)疾病提供創(chuàng)新治療和干預(yù)方案。
實(shí)驗(yàn)室近期的研究方向包括：
1. 精神類疾病藥物藥理特征研究
2. 與神經(jīng)系統(tǒng)疾病相關(guān)的孤兒受體配體發(fā)現(xiàn)
3. 以結(jié)構(gòu)為導(dǎo)向的靶向藥物設(shè)計(jì)?

承擔(dān)科研項(xiàng)目情況：

代表論著：

?^#第一作者，^*通訊作者
1. Z. Chen^#, J. Yu^#, H. Wang^#, P. Xu^#, L. Fan, F. Sun, S. Huang, P. Zhang, H. Huang, S. Gu, B. Zhang, Y. Zhou, X. Wan, G. Pei, H E. Xu^*, J. Cheng^*, S. Wang^*. Flexible Scaffold-based Cheminformatics Approach for Polypharmacological Drug Design. Cell.187:1-15(2024).
2. D. Cao^#, P. Zhang^#, S. Wang^*. Advances in structure-based drug design: The potential for precision therapeuticsin psychiatric disorders. Neuron. 112(4):526-538(2024).
3. Y. Wang^#, P. Zhang^#, Y. Chao^#, Z. Zhu^#, C. Yang^#, Z. Zhou^#, Y. Li, Y. Long, Y. Liu, D. Li, S. Wang^* and Q. Qu^*. Transport and inhibition mechanism for VMAT2-mediatedsynaptic vesicle loading of monoamines. Cell Res., 34(1):47-57(2024).
4. W. Duan^#, D. Cao^#, S. Wang^*, J. Cheng^*. Serotonin 2A Receptor (5-HT2AR) Agonists: Psychedelics and NonHallucinogenic Analogues as Emerging Antidepressants. Chem. Rev., 124(1):124-163(2023).
5. H. Liu^#, Y. Zheng^#, Y. Wang^#, Y. Wang^#, X. He, P. Xu, S. Huang, Q. Yuan, X. Zhang, L. Wang, K. Jiang, H .Chen, Z .Li, W. Liu^*, S. Wang^*, HE Xu^*, F. Xu^*. Recognition of methamphetamine and other amines by trace amine receptor TAAR1. Nature. 624(7992):663-671(2023).
6. R. Liu^#, J. Qi^#, H. Wang, L. Fan, P. Zhang, J. Yu, L. Tan, S. Wang^*, J. Cheng^*. Transformation of a Dopamine D2?Receptor Agonist to Partial Agonists as Novel Antipsychotic Agents. J Med Chem., 66(9):6274-6287(2023).
7. L. He^#, Q. Zhao^#, J. Qi^#, Y. Wang^#, W. Han, Z. Chen, Y. Cong^*, S. Wang^*. Structural insights into constitutive activity of 5-HT₆ receptor. PNAS, 120(14):e2209917120 (2023).
8. L. Yu^#, L. He^#, B. Gan^#, R. Ti^#, Q. Xiao, H. Hu, L. Zhu^*, S. Wang^*, R. Ren^*. Structural insights into sphingosine-1-phosphate receptor activation. PNAS, 119(16): e2117716119 (2022).
9. J. Wang^#, M. Wu^#, Z. Chen^#, L. Wu, T. Wang, D. Cao, H. Wang, S. Liu, Y. Xu, F. Li, J. Liu, N. Chen, S. Zhao, J. Cheng^*, S. Wang^*, T. Hua^*. The unconventional activation of the muscarinic acetylcholine receptor M4R by diverse ligands. Nat. Commun., 13:2855 (2022).?
10. D. Cao^#, J. Yu^#, H. Wang^#, Z. Luo^#, X. Liu^#, L. He, J. Qi, L. Fan, L. Tang, Z. Chen, J. Li, J. Cheng^*&S. Wang^*. Structure-based discovery of non-hallucinogenic psychedelic analogs. Science, 375: 403-411(2022).
11. Z. Chen^#, L. Fan^#, H. Wang^#, J. Yu^#, D. Lu^#, J. Qi, F. Nie, Z. Luo, Z. Liu, J. Cheng^*&S. Wang^*. Structure-based design of a novel third-generation antipsychotic drug lead with antidepressant properties. Nat. Neurosci., 25(1):39-49 (2022).(Cover Story)
12. L. Fan^#, L. Tan^#, Z. Chen, J. Qi, F. Nie, Z. Luo, J. Cheng^*&S. Wang^*, Haloperidol bound D₂ dopamine receptor structure inspired the discovery of subtype selective ligands.?Nat. Commun., 11:1074 (2020).
13. S. Wang^*, T. Che, A. Levit, B. K. Shoichet, D. Wacker^*& B. L. Roth^*, Structure of the D₂ dopamine receptor bound to the atypical antipsychotic drug risperidone.?Nature, 555(7695):269-273 (2018).
14. S. Wang^#^,^*, D. Wacker^#^,*, A. Levit^#, T. Che, R. M. Betz, J. D. McCorvy, A. J. Venkatakrishnan, X.P. Huang, R. O. Dror, B. K. Shoichet^*& B. L. Roth^*, High Resolution Structures of the D₄ Dopamine Receptor Template the Discovery of Novel Specific Agonists.?Science, 358, 381-386 (2017).
15. J. Lyu^#,?S. Wang^#, T. E. Balius^#, I. Singh^#, A. Levit, Y. S. Moroz, M. J. O’Meara, T. Che, E. Algaa, K. Tolmachova, A. A. Tolmachev, B. K. Shoichet^*, B. L. Roth^*& J. J. Irwin^*, Ultra-large Library Docking for Discovering New Chemotypes.?Nature, 566(7743):224-229 (2019).
16. J. D. McCorvy^#^,*, D. Wacker^#,?S. Wang^#, B. Agegnehu, J. Liu, K. Lansu, A. R. Tribo, R. H. J. Olsen, T. Che, J. Jin& B. L. Roth^*. Structural Determinants of 5-HT2B Receptor Activation and Biased Agonism.?Nat. Struct. Mol. Biol., 25(9):787-796 (2018).
17. D. Wacker^#^,*,?S. Wang^#, J. D. McCorvy^#, R. M. Betz, A. J. Venkatakrishnan, A. Levit, K. Lansu, Z. L. Schools, T. Che, D. E. Nichols, B. K. Shoichet, R. O. Dror^*& B. L. Roth^*. Crystal structure of an LSD bound human serotonin receptor.?Cell, 168, 377-389 (2017). (Cover Story)

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研究工作：

承擔(dān)科研項(xiàng)目情況：

代表論著：

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研究組成員：