人人操在线_99影视_亚洲三级片av日日夜夜亲亲摸摸_亚洲人成网亚洲欧洲无码一级毛片_91青青草原网站_含羞草夜夜久无码一区二区_国产综合伦理_2020AV天天日天天射_日日操夜夜操B_又粗又硬免费视频__超碰牛牛精品亚洲_一级毛片特黄免费_欧美日韩亚洲网曝在线_无码毛片网

　　2001年畢業(yè)于山東大學(xué)，獲學(xué)士學(xué)位;2006年畢業(yè)于中科院生化與細(xì)胞所，獲博士學(xué)位。2006年12月至2012年7月于美國哈佛醫(yī)學(xué)院/以色列女執(zhí)事醫(yī)學(xué)中心(Harvard Medical School/Beth Israel Deaconess Medical Center)從事博士后研究。2012年7月底回國就任中國科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所研究員，研究組長。

腫瘤細(xì)胞的一個(gè)重要特征是近乎無限的分裂增殖。這種表型可能由多種生理過程的異常所引起，包括細(xì)胞周期負(fù)調(diào)因子的缺失突變、細(xì)胞代謝途徑的超?；钴S、關(guān)鍵信號通路的活化及細(xì)胞凋亡通路的異常等。本實(shí)驗(yàn)室的研究興趣主要集中于調(diào)控腫瘤細(xì)胞生長增殖的核心信號轉(zhuǎn)導(dǎo)與細(xì)胞代謝調(diào)節(jié)機(jī)制方面，特別是發(fā)現(xiàn)關(guān)鍵信號蛋白的重要翻譯后修飾，從而詮釋腫瘤細(xì)胞生長增殖/癌癥發(fā)生發(fā)展的分子機(jī)制，并為癌癥的臨床治療提供新的思路與治療靶點(diǎn)。

1. Gao, D., H. Inuzuka, A. Tseng, R. Y. Chin, A. Toker, and W. Wei*. "Phosphorylation by Akt1 Promotes Cytoplasmic Localization of Skp2 and Impairs Apccdh1-Mediated Skp2 Destruction." Nature Cell Biology , no. 4 (2009): 397-408.
2. Gao, D., H. Inuzuka, M. Korenjak, A. Tseng, T. Wu, L. Wan, M. Kirschner, N. Dyson, and W. Wei*. "Cdh1 Regulates Cell Cycle through Modulating the Claspin/Chk1 and the Rb/E2f1 Pathways." Molecular Biology of the Cell , no. 14 (2009): 3305-16.
3. Gao, D., L. Wan, H. Inuzuka, A. H. Berg, A. Tseng, B. Zhai, S. Shaik, E. Bennett, A. E. Tron, J. A. Gasser, A. Lau, S. P. Gygi, J. W. Harper, J. A. DeCaprio, A. Toker, and W. Wei*. "Rictor Forms a Complex with Cullin-1 to Promote Sgk1 Ubiquitination and Destruction." Molecular Cell , no. 5 (2010): 797-808.
4. Gao, D., H. Inuzuka, M. K. Tan, H. Fukushima, J. Locasale, P. Liu, L. Wan, B. Zhai, Y. R. Chin, S. Shaik, C. Lyssiotis, S. Gygi, A. Toker, L. Cantley, J. Asara, J. W. Harper, and W. Wei*. "Mtor Drives Its Own Activation Via Scf Βtrcp-Dependent Degradation of the Mtor Inhibitor Deptor." Molecular Cell, no. 2 (2011): 290-303.
5. Inuzuka, H., D. Gao, L. W. S. Finley, W. Yang, L. Wan, H. Fukushima, Y. R. Chin, B. Zhai, S. Shaik, A. W. Lau, Z. Wang, S. P. Gygi, K. Nakayama, J. Teruya-Feldstein, A. Toker, M. C. Haigis, P. P. Pandolfi, and W. Wei*. "Acetylation-Dependent Regulation of Skp2 Function." Cell, no. 1 (2012): 179-93.
6. Hu, H., W. Zhu, J. Qin, M. Chen, L. Gong, L. Li, X. Liu, Y. Tao, H. Yin, H. Zhou, L. Zhou, D. Ye, Q. Ye, and D. Gao.* "Acetylation of Pgk1 Promotes Liver Cancer Cell Proliferation and Tumorigenesis." Hepatology , no. 2 (2017): 515-28.
7. Liu, X., M. Chen, L. Li, L. Gong, H. Zhou, and D. Gao.* "Extracellular Signal-Regulated Kinases (Erks) Phosphorylate Lin28a Protein to Modulate P19 Cell Proliferation and Differentiation." Journal of Biological Chemistry , no. 10 (2017): 3970-76.
8. Xie, X., H. Hu, X. Tong, L. Li, X. Liu, M. Chen, H. Yuan, X. Xie, Q. Li, Y. Zhang, H. Ouyang, M. Wei, J. Huang, P. Liu, W. Gan, Y. Liu, A. Xie, X. Kuai, G. W. Chirn, H. Zhou, R. Zeng, R. Hu, J. Qin, F. L. Meng, W. Wei, H. Ji, and D. Gao.* "The Mtor-S6k Pathway Links Growth Signalling to DNA Damage Response by Targeting Rnf168." Nature Cell Biology , no. 3 (2018): 320-31.
9. Cui, B., L. Gong, M. Chen, Y. Zhang, H. Yuan, J. Qin, and D. Gao.* "Cul5-Socs6 Complex Regulates Mtorc2 Function by Targeting Sin1 for Degradation." Cell Discovery , no. 1 (2019).
10. Zhao, G., L. Gong, D. Su, Y. Jin, C. Guo, M. Yue, S. Yao, Z. Qin, Y. Ye, Y. Tang, Q. Wu, J. Zhang, B. Cui, Q. Ding, H. Huang, L. Hu, Y. Chen, P. Zhang, G. Hu, L. Chen, K. K. Wong, D. Gao*, and H. Ji*."Cullin5 Deficiency Promotes Small-Cell Lung Cancer Metastasis by Stabilizing Integrin Β1." Journal of Clinical Investigation , no. 3 (2019): 972-87.
11. Kuai, X., L. Li, R. Chen, K. Wang, M. Chen, B. Cui, Y. Zhang, J. Li, H. Zhu, H. Zhou, J. Huang, J. Qin, Z. Wang, W. Wei, and D. Gao.* "Scffbxw7/Gsk3β-Mediated Gfi1 Degradation Suppresses Proliferation of Gastric Cancer Cells." Cancer Research , no. 17 (2019): 4387-98.
12. Gao, Q., H. Zhu, L. Dong, W. Shi, R. Chen, Z. Song, C. Huang, J. Li, X. Dong, Y. Zhou, Q. Liu, L. Ma, X. Wang, J. Zhou, Y. Liu, E. Boja, A. I. Robles, W. Ma, P. Wang, Y. Li, L. Ding, B. Wen, B. Zhang, H. Rodriguez, D. Gao,* H. Zhou,* and J. Fan*. "Integrated Proteogenomic Characterization of Hbv-Related Hepatocellular Carcinoma." Cell , no. 2 (2019): 561-77.e22.
13. Dong, L., D. Lu, R. Chen, Y. Lin, H. Zhu, Z. Zhang, S. Cai, P. Cui, G. Song, D. Rao, X. Yi, Y. Wu, N. Song, F. Liu, Y. Zou, S. Zhang, X. Zhang, X. Wang, S. Qiu, J. Zhou, S. Wang, X. Zhang, Y. Shi, D. Figeys, L. Ding, P. Wang, B. Zhang, H. Rodriguez, Q. Gao,* D. Gao,* H. Zhou,* and J. Fan.* "Proteogenomic Characterization Identifies Clinically Relevant Subgroups of Intrahepatic Cholangiocarcinoma." Cancer Cell, no. 1 (2022): 70-87.e15.
14. Luo, D., M. Chen, Q. Li, K. Wang, K. Wang, J. Li, G. Fu, Z. Shan, Q. Liu, Y. Yang, L. Liang, Y. Ma, Y. Qin, J. Qin, D. Gao, *and X. Li.* "Cul4b-Ddb1-Cop1-Mediated Utx Downregulation Promotes Colorectal Cancer Progression." Experimental Hematology and Oncology , no. 1 (2023).
15. Chen, M., K. Wang, Y. Han, S. Yan, H. Yuan, Q. Liu, L. Li, N. Li, H. Zhu, D. Lu, K. Wang, F. Liu, D. Luo, Y. Zhang, J. Jiang, D. Li, L. Zhang, H. Ji, H. Zhou, *Y. Chen, *J. Qin,* and D. Gao.* "Identification of Xaf1 as an Endogenous Akt Inhibitor." Cell Reports , no. 7 (2023).
16. Duan, J., Y. Zhang, R. Chen, L. Liang, Y. Huo, S. Lu, J. Zhao, C. Hu, Y. Sun, K. Yang, M. Chen, Y. Yu, J. Ying, R. Huang, X. Ma, S. Leaw, F. Bai, Z. Shen, S. Cai, D. Gao, J. Wang, *and Z. Wang.* "Tumor-Immune Microenvironment and Nrf2 Associate with Clinical Efficacy of Pd-1 Blockade Combined with Chemotherapy in Lung Squamous Cell Carcinoma." Cell Reports Medicine , no. 12 (2023).
17. Gao, D., and G. Ge. "Exploring the Underlying Biology of Cancer and Potential Therapeutic Strategies: A Special Issue Focused on Mechanism-Based Studies." Acta Biochimica et Biophysica Sinica , no. 6 (2023): 891-92.
18. Liu, Q., J. Zhang, C. Guo, M. Wang, C. Wang, Y. Yan, L. Sun, D. Wang, L. Zhang, H. Yu, L. Hou, C. Wu, Y. Zhu, G. Jiang, H. Zhu, Y. Zhou, S. Fang, T. Zhang, L. Hu, J. Li, Y. Liu, H. Zhang, B. Zhang, L. Ding, A. I. Robles, H. Rodriguez, D. Gao,* H. Ji,* H. Zhou,* and P. Zhang.* "Proteogenomic Characterization of Small Cell Lung Cancer Identifies Biological Insights and Subtype-Specific Therapeutic Strategies." Cell , no. 1 (2024): 184-203.e28.
19. Yu, J., X. Gui, Y. Zou, Q. Liu, Z. Yang, J. An, X. Guo, K. Wang, J. Guo, M. Huang, S. Zhou, J. Zuo, Y. Chen, L. Deng, G. Yuan, N. Li, Y. Song, J. Jia, J. Zeng, Y. Zhao, X. Liu, X. Du, Y. Liu, P. Wang, B. Zhang, L. Ding, A. I. Robles, H. Rodriguez, H. Zhou,* Z. Shao,* L. Wu,* and D. Gao.* "A Proteogenomic Analysis of Cervical Cancer Reveals Therapeutic and Biological Insights." Nature Communications , no. 1 (2024).
20. Wang, K., M. Chen, S. Yan, Y. Han, H. Yuan, Q. Liu, D. Lu, L. Li, K. Wang, F. Liu, Q. Li, D. Luo, J. Jiang, H. Zhou,* Y. Chen,* J. Qin,* and D. Gao.* "Zinc Ions Activate Akt and Promote Prostate Cancer Cell Proliferation Via Disrupting Akt Intramolecular Interaction." Oncogene , no. 1 (2025): 8-18.
21. Gao, D., and J. W. P. Yam. "Reversal of Lipid Metabolism as a Therapeutic Approach for Hcc." Hepatology , no. 4 (2025): 1113-15.
22. Chen, R., C. Ma, H. Qian, X. Xie, Y. Zhang, D. Lu, S. Hu, M. Zhang, F. Liu, Y. Zou, Q. Gao, H. Zhou, H. Liu, M. Lin,* G. Ge,* and D. Gao.* "Mutant Kras and Ck2 Cooperatively Stimulate Slc16a3 Activity to Drive Intrahepatic Cholangiocarcinoma Progression." Cancer Research , no. 7 (2025): 1253-69.
23. Ji, S., L. Cao, J. Gao, Y. Du, Z. Ye, X. Lou, F. Liu, Y. Zhang, J. Xu, X. Shi, H. Wang, P. Li, Y. Li, H. Chen, Z. Yang, S. Gao, W. Zhang, D. Huang, S. Ni, M. Wei, F. Wang, Y. Wang, T. Ding, D. Jing, G. Fan, Z. Gong, R. Lu, Y. Qin, J. Chen, X. Xu, P. Wang, B. Zhang, L. Ding, A. I. Robles, H. Rodriguez, D. K. Chang, R. H. Hruban, D. Gao, D.* Gao, G.* Jin, H.* Zhou,* J. Wu,* and X. Yu.* "Proteogenomic Characterization of Non-Functional Pancreatic Neuroendocrine Tumors Unravels Clinically Relevant Subgroups." Cancer Cell , no. 4 (2025): 776-96.e14.