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2001年獲武漢大學學士學位，2007年獲中科院上海生科院健康科學研究所博士學位，2008至2013年在美國安德森癌癥中心(MD Anderson Cancer Center)做博士后研究，并成為奧德賽學者(Odyssey Fellow)。2013年8月起擔任中科院生物化學與細胞生物學研究所研究員，研究組長，博士生導師。

腫瘤細胞的代謝重塑在腫瘤發(fā)生發(fā)展中發(fā)揮至關重要的作用。腫瘤細胞響應功能基因突變和多變的環(huán)境因素，如營養(yǎng)物、生長因子、免疫細胞和飲食等，主動調節(jié)代謝途徑的通量、甚至改變特定途徑的走向，以滿足腫瘤細胞無限增殖所需的生物大分子合成原料、能量以及氧化還原穩(wěn)態(tài)。此外，特定功能基因的突變還會導致一些有活性的代謝中間產物異常累積，進而通過調控基因的表達和信號轉導的激活加速腫瘤生長，并促進腫瘤轉移和治療抵抗。只有充分解析這些過程才能發(fā)現(xiàn)腫瘤代謝重塑的關鍵節(jié)點，并轉化為新型癌癥治療手段。

1. 腫瘤細胞的代謝重塑

2. 腫瘤免疫微環(huán)境的代謝調控

3. 代謝物豐度感知

（*Corresponding author）

1. Zhu W, Chu H, Zhang Y, Luo T, Yu H, Zhu H, Liu Y, Gao H, Zhao Y, Li Q*, Wang X*, Li G*, Yang W* Fructose-1,6-bisphosphatase 1 dephosphorylates IκBα and suppresses colorectal tumorigenesis. Cell Res. 2023 Mar;33(3):245-257.
2. Zhang Y, Zhao M, Gao H, Yu G, Zhao Y*, Yao F*, Yang W*. MAPK signaling-induced Phosphorylation and Subcellular Translocation of PDHE1α Promotes Tumor Immune Evasion. Nat Metab. 2022 Mar;4(3):374-388.
3. Wu S, Cao R, Tao B, Wu P, Peng C, Gao H, Liang J*, Yang W*. Pyruvate facilitates FACT-mediated γH2AX loading to chromatin and promotes the radiation resistance of glioblastoma. Adv Sci. 2022 Jan 20;e2104055.
4. Zhang Y, Yu H, Zhang J, Gao H, Wang S, Li S, Wei P, Liang J, Yu G, Wang X*, Li X*, Li D* and Yang W*. Cul4A-DDB1-mediated monoubiquitination of phosphoglycerate dehydrogenase promotes colorectal cancer metastasis via increased S-adenosylmethionine. J Clin Invest, 2021 Nov 1;131(21):e146187:1-18.
5. Wang X, Liu R, Zhu W, Qu X, Yu H, Chu H, Zhang Y, Zhu W, Wu X, Gao H, Tao B, Li W, Liang J, Li G*, Yang W*. α-Ketoglutarate-activated NF-κB signaling promotes compensatory glucose uptake and brain tumor development. Mol Cell, 2019 Oct 3;76(1):148-162
6. Wang X, Liu R, Zhu W, Chu H, Yu H, Wei P, Wu X, Zhu H, Gao H, Liang J, Li G*, Yang W*. UDP-glucose accelerates SNAI1 mRNA decay and impairs lung cancer metastasis. Nature, 2019 Jul; 571(7763):127-131.
7. Liu R, Li W, Tao B, Wang X, Yang Z, Zhang Y, Wang C, Liu R, Gao H, Liang J, Yang W*. Tyrosine phosphorylation activates 6-phosphogluconate dehydrogenase and promotes tumor growth and radiation resistance. Nat Commun, 2019 Mar 1; 10(1):991:1-13.
8. Jin G, Zhang Y, Cong W, Wu X, Wang X, Wu S, Wang S, Zhou W, Yuan S, Gao H, Yu G*, Yang W*. Phosphoglucomutase 1 inhibits hepatocellular carcinoma progression by regulating glucose trafficking. PLOS Biol, Oct; 16(10): e2006483:1-27.
9. Zhang Y, Yu G, Chu H, Wang X, Xiong L, Cai G, Liu R, Gao H, Tao B, Li W, Li G*, Liang J, Yang W*. Macrophage-associated PGK1 phosphorylation promotes aerobic glycolysis and tumorigenesis. Mol Cell, 2018 Jul 19;71(2):201-215
10. Liang J, Cao R, Wang X, Zhang Y, Wang P, Gao H, Li C, Yang F, Zeng R, Wei P, Li D, Li W and Yang W*. Mitochondrial PKM2 regulates oxidative stress-induced apoptosis by stabilizing Bcl2. Cell Res, 2017 Mar; 27(3):329-351.
11. Liang J, Cao R, Zhang Y, Xia Y, Zheng Y, Li X, Wang L, Yang W*, Lu Z*. PKM2 dephosphorylation by Cdc25A promotes the Warburg effect and tumorigenesis. Nat Commun, 2016 Aug 3; 7:12431.
12. Yang W, Zheng Y, Xia Y, Ji H, Chen X, Guo F, Lyssiotis C, Aldape K, Cantley L, Lu Z*. ERK1/2-dependent nuclear translocation of PKM2 promotes the Warburg effect. Nat Cell Biol. 2012 Dec; 14(12): 1295–1304.
13. Yang W, Xia Y, Cao Y, Zheng Y, Bu W, Zhang L, You MJ, Koh MY, Cote G, Aldape K, Li Y, Verma IM, Chiao PJ, Lu Z*. EGFR-induced and PKCε monoubiquitylation-dependent NF-κB activation upregulates PKM2 expression and promotes tumorigenesis. Mol Cell, 2012 Dec 14; 48(5):771-84.
14. Yang W, Xia Y, Hawke D, Li X, Liang J, Xing D, Aldape K, Hunter T, Yung W, Lu Z*. PKM2 phosphorylates Histone H3 and promotes gene transcription and tumorigenesis. Cell, 2012 Aug 17; 150(4):685-96.
15. Yang W, Xia Y, Ji H, Zheng Y, Liang J, Huang W, Gao X, Aldape K, Lu Z*. Nuclear PKM2 regulates beta-catenin transactivation upon EGF stimulation. Nature, 2011 Dec 1; 480(7375):118-22.