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　　2013年畢業(yè)于中國科學(xué)院上海生命科學(xué)研究院，獲博士學(xué)位;

　　2013年底在美國Stowers/HHMI研究所從事博士后研究。

　　2019年10月回國就任中國科學(xué)院生物化學(xué)與細(xì)胞生物學(xué)研究所研究員，研究組長。

探索生命的再生機(jī)制：解析人類疾病與衰老

再生是大自然最為神奇的現(xiàn)象之一，使得生物體能夠修復(fù)和替代受損的組織。這一非凡的能力在動物界不同物種和不同器官廣泛存在，但支配器官再生的細(xì)胞與分子機(jī)制仍然鮮為人知。我們的研究旨在揭示這些基礎(chǔ)機(jī)制，探索驅(qū)動組織修復(fù)與再生的動態(tài)過程。

我們團(tuán)隊(duì)的研究工作以創(chuàng)新的模型系統(tǒng)為核心，力圖提供前所未有的視角，深入解析影響再生潛力的遺傳與環(huán)境因素。通過運(yùn)用最前沿的技術(shù)，如功能基因組學(xué)、空間轉(zhuǎn)錄組學(xué)、單細(xì)胞RNA測序和高分辨率成像，我們正在解析跨物種的再生生物學(xué)細(xì)胞及分子機(jī)制。這種跨學(xué)科的研究方法使我們能夠發(fā)現(xiàn)不同物種中再生的核心原理。

我們特別關(guān)注具有強(qiáng)大再生潛力的系統(tǒng)（如淡水渦蟲）與再生能力有限的系統(tǒng)（如心臟）的比較研究，從而全面理解再生過程。這些研究不僅探索了不同物種如何利用獨(dú)特的再生能力，也致力于將這些發(fā)現(xiàn)轉(zhuǎn)化為改善人類再生療法的關(guān)鍵技術(shù)。

我們最終的目標(biāo)是利用再生的力量，推動新的治療方法，用于對抗退行性疾病、促進(jìn)組織修復(fù)，并延長人類的壽命。通過深入理解生物體如何實(shí)現(xiàn)再生，我們旨在革新再生醫(yī)學(xué)，并為癌癥相關(guān)的組織損傷提供變革性的解決方案，同時(shí)開辟人類健康的突破性新途徑。

1. Fan L, Tang Q, Wang YT, Sun H, Li G, Yang Y, Zhu HY, Liu ZY, Wang H, Wang H, Jing Q, Antos CL, Xiao H,Guan RC, Pei G, Ginhoux F, Zhou ZG*, & Zeng A*, Injury-induced Clusterin+ cardiomyocytes suppress inflammation and promote regeneration in neonatal and adult hearts by reprogramming macrophages. Cell Stem Cell (2025), In press. (Co-corresponding author, lead contact)
2. Yan Y, Sun DQ, Hu J, Chen Y, Sun LD, Yu HS, Xiong YC, Huang ZD, Xia HR, Zhu XS, Bian DL, Sun FH, Hou LK, Wu CY, Fan OR, Hu HY, Zeng A^*, Zhang LL, Sun YE, Wang CF, Zhang P. Multi-omic profiling highlights factors associated with resistance to immuno-chemotherapy in non-small-cell lung cancer. Nat Genet (2024),
3. Chen SY^#, Zheng YJ^#, Ran XJ^#, Du H, Feng H, Yang L, Wen Y, Lin CD, Wang SH, Huang MW, Yan ZJ, Wu D, Wang HY, Ge GX, Zeng A*, Zeng YA*, Chen JF*. Integrin αEβ7+ T cells direct intestinal stem cell fate decisions via adhesion signaling. Cell Research, doi:10.1038/s41422-021-00561-2. （Co-corresponding author）
4. Wang W, Hu CK, Zeng A, Alegre D, Hu DQ, Gotting K, Granillo AO, Wang YF, Robb S, Schnittker R, Zhang SS, Alegre D, Li H, Ross E, Zhang N, Brunet A, Sanchez Alvarado A. Changes in regeneration-responsive enhancers shape regenerative capacities in vertebrates. Science, 2020; 369(6508), eaaz3093.
5. Zeng A, Li H, Guo LH, Gao X, McKinney S, Wang YF, Yu ZL, Park J, Semerad C, Ross E, Cheng, LC, Davies, E, Lei, K, Wang W, Perera A, Hall K, Peak A, Box A, Sanchez Alvarado A. Prospectively isolated Tetraspanin+ neoblasts are adult pluripotent stem cells that underlie planaria regeneration. Cell, 2018;173(7):1593-1608.
6. Zeng A, Li YQ, Wang C, Han XS, Li G, Wang JY, Li DS, Qin YW, Shi YF, Brewer G, Jing Q. Heterochromatin protein 1 promotes self-renewal and triggers regenerative proliferation in adult stem cells. Journal of Cell Biology, 2013;201(3):409-25.
7. Wang C, Yang ZZ, Guo FH, Shi S, Han XS, Zeng A, Lin HF, Jing Q, Heat shock protein DNAJA1 stabilizes PIWI proteins to support regeneration and homeostasis of planarian Schmidtea mediterranea. Journal of Biological Chemistry, (doi: 10.1074/jbc.RA118.004445), 2019.
8. Li Y, Zeng A, Han XS, Li G, Li YQ, Shen B, Jing Q. Small RNAome sequencing delineates the small RNA landscape of pluripotent adult stem cells in the planarian Schmidtea mediterranea. Genomics Data, 2017 Dec; 14:114-125.
9. Li Y, Zeng A, Li G, Guan YN, Yang, HT, Shen B. Jing Q. Dynamic regulation of small RNAome during the early stage of cardiac differentiation from pluripotent embryonic stem cells. Genomics Data, 2017 May; 12:136-145.
10. Tian FJ, An LN, Wang GK, Zhu JQ, Li Q, Zhang YY, Zeng A, Zou J, Zhu RF, Han XS, Shen N, Yang HT, Zhao XX, Huang S, Qin YW, Jing Q. Elevated microRNA-155 promotes foam cell formation by targeting HBP1 in atherogenesis. Cardiovascular Research, 2014;103(1):100-110.
11. Li YQ, Zeng A, Han XS, Wang C, Li G, Zhang ZC, Wang JY, Qin YW, Jing Q. Argonaute-2 regulates the proliferation of adult stem cells in planarian. Cell Research, 2011;21(12):1750-4.
12. Qi MY, Wang ZZ, Zhang Z, Shao Q, Zeng A, Li XQ, Li WQ, Wang C, Tian FJ, Li Q, Zou J, Qin YW, Brewer G, Huang S, Jing Q. AU-Rich element-dependent translation repression requires the cooperation of Tristetraprolin and RCK/P54. Mol Cell Biol, 2012;32(5):913-28.
13. Zhang ZC, Zeng A, Han XS, Li YQ, Jing Q. HDAC-1 determines adult stem cell maintenance in planarian. Journal of Shanghai Jiaotong University (Medical Science), 2013; 09-1202-07.